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Option 1 : Idiosyncratic reactions
Concept:
- Idiosyncratic reactions these are the adverse effects that cannot be explained by known mechanisms
- Idiosyncratic drug reactions are a significant cause of morbidity and mortality for patients; they also markedly increase the uncertainty of drug development.
- The major targets are skin, liver, and bone marrow.
- Clinical characteristics suggest that IDRs are immune mediated
- For example a patient with monoclonus infection developed rashes immediately after administration of ampicilline
- Allergic reactions are most common side effects of all the drugs which includes skin rashes, erythematous skin lesions
- Drug toxicity can damage the organ or entire system of a person the common toxic reactions include anxiety, restlessness, hallucinations, high temperature, chest pain etc.,
- Close observation and exact drug calculation is required to avoid such drug toxicity
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