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Sometimes intact charged protein generated by ESI is introduced into the mass analyzer and is subjected to gas-phase fragmentation. What is this type of approach called?

Sometimes intact charged protein generated by ESI is introduced into the mass analyzer and is subjected to gas-phase fragmentation. What is this type of approach called? Correct Answer “Top-down” strategy of protein analysis

In the “top-down” strategy of protein analysis the charged protein generated by ESI is introduced into the mass analyzer and is subjected to gas-phase fragmentation. This approach starts with intact protein and leads to fragmented protein, therefore, it is known as the “top-down” strategy of protein analysis.

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