Protein Engineering MCQ

Test your knowledge with important Protein Engineering MCQ and their applications. These MCQs are beneficial for competitive exams too. Explore 30 + more Protein Engineering MCQs at Bissoy

• Both the subunits of heterodimers are involved in tRNA binding.
  ক

  False

  খ

  True
• The tRNA makes contact with the synthetase at only a single specific position.
  ক

  True

  খ

  False
• Tyrosine is activated at an amino group with ATP to form tyrosyl adenylate.
  ক

  True

  খ

  False
• The charging of tRNATyr with tyrosine is a single-stage reaction.
  ক

  True

  খ

  False
• Which of the following amino acids can be used in place of lysine, arginine, and histidine to remove the electrostatic charge but retain the hydrophilic nature of the side chain?
  ক

  Aspartic acid and glutamic acid

  খ

  Aspartic acid and glutamine

  গ

  Asparagine and glutamic acid

  ঘ

  Asparagine and glutamine
• In tRNA charging, the Km (ATP) is unaffected in the heterodimer, but the Kcat is one half that of wild type enzyme.
  ক

  False

  খ

  True
• Which of the following shaped structure is formed by the tRNATyr ?
  ক

  J-shaped

  খ

  O-shaped

  গ

  I-shaped

  ঘ

  L-shaped
• The C-terminal domain of tyrosyl-tRNA synthetase contains major binding determinants for the tRNA.
  ক

  False

  খ

  True
• Which of the following enzyme catalyzes the charging of tRNATyr with tyrosine?
  ক

  Tyrosine synthetase

  খ

  RNA activating enzyme

  গ

  Tyrosyl-tRNA synthase

  ঘ

  Tyrosyl-tRNA synthetase
• Protein-based subunit vaccines initiate T cell-dependent activation of B cells.
  ক

  False

  খ

  True
• Most viral vaccines are thought to work by which of the following technique?
  ক

  Inducing the production of antigens

  খ

  Inducing the production of cell wall

  গ

  Inducing the production of cytosolic proteins

  ঘ

  Inducing the production of antibodies
• The first recombinant vaccine produced targeted the surface antigen of which of the following virus?
  ক

  DENV1

  খ

  Ebola virus

  গ

  Hepatitis A virus

  ঘ

  Hepatitis B virus
• Which of the following is the only way to control pertussis?
  ক

  Antibiotic treatment

  খ

  Heavy medications

  গ

  Accurate diagnosis

  ঘ

  Vaccination
• Dengue virus belongs to which of the following category?
  ক

  Lentivirus

  খ

  Coronavirus

  গ

  Filovirus

  ঘ

  Flavivirus
• Which of the following is not the way in which antibodies participate in host defense?
  ক

  Opsonization

  খ

  Enhance uptake by phagocytic cells

  গ

  Activation of complement proteins

  ঘ

  Directly destroy the antigen
• Antibiotic treatment is very effective in clearing Bordetella pertussis and the disease caused by it.
  ক

  True

  খ

  False
• Which of the following is the pathogen of Pertussis?
  ক

  Staphylococcus aureus

  খ

  Salmonella typhi

  গ

  Clostridium botulinum

  ঘ

  Bordetella pertussis
• Influenza is a DNA virus that causes respiratory tract infections in mammals and some bird species.
  ক

  True

  খ

  False
• Which of the following toxin does not have ADP-ribosylation activity?
  ক

  Pertussis toxin

  খ

  E. coli heat-labile toxin

  গ

  Cholera toxin

  ঘ

  Botulinum toxin A
• The chemical reaction in chemical detoxification should be reversible.
  ক

  True

  খ

  False
• Neutralizing antibodies do not abrogate viral infectivity by which of the following mechanisms?
  ক

  Inhibiting viral uncoating

  খ

  Blocking virus attachment to host cells

  গ

  Inducing the formation of non-infectious viral aggregates

  ঘ

  Degrading the virus directly
• In chemically detoxified vaccines the structural epitopes of the pathogen should be destroyed.
  ক

  True

  খ

  False
• Infection of HIV-1 is initiated by the binding of gp120 to CD4 and a co-receptor on host cells, triggering large scale conformational changes in gp41 that eventually lead to membrane fusion.
  ক

  False

  খ

  True
• The chemically detoxified vaccines are very efficacious and inexpensive.
  ক

  False

  খ

  True
• APC inactivates FVIIIa by proteolytic cleavage at which of the following sites?
  ক

  R313 and/or R512

  খ

  R454 and/or R565

  গ

  R234 and/or R554

  ঘ

  R336 and/or R562
• How many alternatively spliced transcripts are produced by factor VIII gene?
  ক

  Five

  খ

  Seven

  গ

  Three

  ঘ

  Two
• The potency of gene therapy vectors can be enhanced by using bioengineered extended half-life (EHL) FVIII or FIX fusion proteins as transgenes.
  ক

  False

  খ

  True
• Removing which of the following enzyme cleavage site impedes the A2 dissociation?
  ক

  Rennin

  খ

  Pepsin

  গ

  Furin

  ঘ

  Thrombin
• Small changes in the amino acid sequence of proteins can have a profound effect on their immunogenicity.
  ক

  False

  খ

  True
• Which of the following can inactivate the activated FVIII?
  ক

  Inactivated protein B

  খ

  Activated protein B

  গ

  Inactivated protein C

  ঘ

  Activated protein C