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In case of Protein-ligand docking, ______ ligands are often _____ in adapting their shape to fit the receptor binding pocket.

In case of Protein-ligand docking, ______ ligands are often _____ in adapting their shape to fit the receptor binding pocket. Correct Answer small molecule, highly flexible

The degree of conformational flexibility of a small molecule ligand (substrate, cofactor or inhibitor) can be considerable particularly where there are multiple torsion angles. This presents a major challenge in protein-ligand docking and several different approaches have been used to solve this problem.

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