Conformational Flexibility MCQ

Test your knowledge with important Conformational Flexibility MCQ and their applications. These MCQs are beneficial for competitive exams too. Explore 30 + more Conformational Flexibility MCQs at Bissoy

• Which of the following is true regarding Protein flexibility?
  ক

  Methods have been described for the introduction of side-chain flexibility to both protein-ligand and protein-protein docking

  খ

  Methods have been described for the introduction of side-chain flexibility to protein-ligand docking only

  গ

  The Mean Field principle is rarely used in this

  ঘ

  Methods have been described for the introduction of side-chain flexibility to protein-protein docking only
• Stochastic methods can guarantee reaching a global optimal solution and the methods are computationally costly in comparison to the other methods.
  ক

  True

  খ

  False
• Genetic methods (genetic algorithms and evolutionary programming) store multiple solutions. These solutions form a population of members.
  ক

  True

  খ

  False
• In a Monte Carlo simulation the score (or energy) is calculated at each step and compared to the previous step. The probability of accepting the step is given by _________ where ΔE is the difference in energy; kB is Boltzmann’s constant and T the temperature.
  ক

  True

  খ

  False
• In Stochastic search methods, they include methods such as Monte Carlo simulation, simulated annealing, Tabu search, genetic algorithms and evolutionary programming.
  ক

  True

  খ

  False
• The disadvantage of Multiple conformation rigid-body method is that the active conformation may be missed as the result of a minor structural difference not considered in the ______ ligand conformations. Where, the N is the number of low-energy conformations.
  ক

  N +1

  খ

  N

  গ

  N2

  ঘ

  N/2
• In Multiple conformation rigid-body method, a ligand is assumed to be able to adopt a number (N) of different _______ that are computed _____ the ligand being docked into the receptor.
  ক

  low-energy conformations, after

  খ

  low-energy conformations, prior to

  গ

  high-energy conformations, prior to

  ঘ

  high-energy conformations, after
• In case of Protein-ligand docking, ______ ligands are often _____ in adapting their shape to fit the receptor binding pocket.
  ক

  small molecule, highly flexible

  খ

  large molecule, highly flexible

  গ

  large molecule, more flexible

  ঘ

  small molecule, less flexible
• Typical motions of proteins will be primarily treated by a rigid body model for docking.
  ক

  True

  খ

  False
• Proteins are dynamic entities that undergo _______
  ক

  only fluctuation of flexible loop regions about equilibrium positions when in solution

  খ

  only limited conformational change of amino acid side-chains when in solution

  গ

  both limited conformational change of amino acid side-chains and fluctuation of flexible loop regions about equilibrium positions when in solution

  ঘ

  illimitable or total conformational change of amino acid side-chains when in solution