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Bioavailability of a drug may be decreased if the drug is
A Water soluble
B Protein in nature
C Ionized
D Acid stable
E Lipid soluble
Bioavailability of a drug is
A A fraction of unchanged drug in the systemic circulation
B Is affected by metabolism in the liver
C 100% with intravenous route
D A measure of the rate of absorption of the drug
E Identical with different formulations of the same drug
Bioavailability of a drug after oral administration may be reduced by:
A Increased rate of first pass metabolism
B Enteric coating of a tablet that is labile in acid pH of stomach
C Interaction with other drugs
D Decreased gastric emptying time
E Increased gastrointestinal blood flow
A drug that is highly effective in treating many types of infection can,at present,be obtained only from the bark of the ibora , a tree that is quite rare in the wild. It takes the bark of 5000 trees to make one kilogram of the drug. It follows, therefore, that continued production of the drug must inevitably lead to the ibore's extinction. Which of the following,if true, most seriously weakens the arguments above ?
A The drug made from the ibora bark is dispensed to doctors from a central authority
B The drug made from the ibora bark is expensive to produce
C The leaves of the ibora are used in a number of medical products
D The ibora can be propagated from cuttings and grown under cultivation
Causes of decreased bioavailability are
A High first pass metabolism
B Poor lipid solubility
C Increased absorption.
D Intravenous absorption of drugs
E Nonionization of drugs
Drugs that can not be given orally are
A Benzyl penicillin
B Gentamicin
C Oxytocin
D Ampicillin
E Nitroglycerin
Drugs used orally are
A Paracetamol
B Nitroglycerine
C Ampicillin
D Insulin
E Heparin
Drugs used orally in the treatment of fungal infection include
A Griseofulvin
B Fluconazol
C Terbinafine
D Azithromycin
E Cephradin
Following subcutaneous injection of a drug into a healthy young adult, dilatation of the pupil and a rise in systolic blood pressure are produced. The drug could be
A Acting by stimulating  and  receptors
B Acting by blocking sympathetic ganglia
C Atropine
D Adrenaline
E Morphine
Fill in the blanks : -----the outcome, the medication has to be administered.
A Regardless of
B Careless of
C Withstanding
D Spite of

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