Bioavailability of a drug after oral administration may be reduced by:

A Increased rate of first pass metabolism
B Enteric coating of a tablet that is labile in acid pH of stomach
C Interaction with other drugs
D Decreased gastric emptying time
E Increased gastrointestinal blood flow

Correct Answer: Increased rate of first pass metabolism, Enteric coating of a tablet that is labile in acid pH of stomach, Interaction with other drugs

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#Diploma #Pharmacology #General pharmacology #Bioavailability

Related Questions

Bioavailability of a drug may be decreased if the drug is
A Water soluble
B Protein in nature
C Ionized
D Acid stable
E Lipid soluble
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A A fraction of unchanged drug in the systemic circulation
B Is affected by metabolism in the liver
C 100% with intravenous route
D A measure of the rate of absorption of the drug
E Identical with different formulations of the same drug
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A Depends on solubility status
B Depends on size of the particle
C Is not influenced by presence of food
D Does not depend on disintegration time
E Usually ranges between 60-70 percent
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A The drug made from the ibora bark is dispensed to doctors from a central authority
B The drug made from the ibora bark is expensive to produce
C The leaves of the ibora are used in a number of medical products
D The ibora can be propagated from cuttings and grown under cultivation
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A Compressibility
B Molecular weight
C Humidity
D None of these
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A High first pass metabolism
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A Substances that are not adjective are not regulated by the Drug Administration
B The tobacco executives lied when they claimed that cigarette smoking was not adjective
C Some adjective substances are not regulated by the Drug Administration.
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A Intravenous
B Subcutaneous
C Intramascular
D Sublingual
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