General pharmacology MCQ 85+

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• The following statements best describe the transmembrane signaling processes involved in the action of predinosolone by activation of
  ক

  Cytoplasmic Heat Shock Protein (HSP 90)

  খ

  The nuclear transcription process

  গ

  Messenger RNA (mRN

  ঘ

  Tyrosine kinase - linked receptor

  ঙ

  G protein that activate adenyl-cyclase
• Following drugs require monitoring when used in renal failure patients
  ক

  Lithium

  খ

  Doxycycline

  গ

  Diazepam

  ঘ

  Propranolol

  ঙ

  Pethidine
• Drugs to be avoided in G6PD deficiency states are
  ক

  Chloroquine

  খ

  Sulfamethoxazole

  গ

  Primaquine

  ঘ

  Digoxin

  ঙ

  Gentamicin
• Following are inconsistent with the criteria of essential drugs
  ক

  May safely be prescribed in pregnancy

  খ

  Are not expected to cause drug interaction

  গ

  Satisfy the health care need of majority people

  ঘ

  Are available at low cost

  ঙ

  Should be included in rational prescription
• Drugs that can produce teratogenesis is:
  ক

  ACE inhibitors

  খ

  Diazepam

  গ

  Ciprofloxacin

  ঘ

  Glibenclamide

  ঙ

  Aspirin
• The following drugs are known to be teratogenic
  ক

  Phenobarbitone

  খ

  Diazepam

  গ

  Tetracycline

  ঘ

  Alpha-methyldopa

  ঙ

  Erythromycin
• The teratogenic drugs are
  ক

  Ciprofloxacin

  খ

  Methotrexate

  গ

  Phenytoin

  ঘ

  Prednisolone

  ঙ

  Rifampicin
• Safe drugs during pregnancy are
  ক

  Insulin

  খ

  α-methyl dopa

  গ

  Ciprofloxacin

  ঘ

  Tetracycline

  ঙ

  Captopril
• Antibiotics safe in pregnancy are
  ক

  Cephalosporin

  খ

  Penicillin

  গ

  Aminoglycosides

  ঘ

  Sulphonamides

  ঙ

  Tetracycline
• Teratogenic drugs are
  ক

  Phenytoin

  খ

  Retinoids

  গ

  Captopril

  ঘ

  Erythromycin

  ঙ

  Folic acid
• The following drugs are definite teratogens
  ক

  Phenytoin

  খ

  Retinoids

  গ

  Salbutamol

  ঘ

  Erythromycin

  ঙ

  Folic Acid
• Maternal drugs considered as risk factors for foetal neural tube defects are
  ক

  Carbamazepine

  খ

  Sodium valporate

  গ

  Levetriacetam

  ঘ

  NSAID

  ঙ

  Prednisolone
• Antimicrobials that should be avoided during pregnancy include
  ক

  Ciprofloxacin

  খ

  Tretracycline

  গ

  Amoxicillin

  ঘ

  Cefuroxime

  ঙ

  Metronidozole
• Regarding postoperative pain management following statements are correct
  ক

  Pain assessment is crucial for dose determination

  খ

  Co-analgesics are useful for patient

  গ

  Preoperative patient education is unnecessary

  ঘ

  Opioids are always associated with addiction

  ঙ

  It is better to avoid NSAIDs
• In pregnancy safe antimicrobial/s is/are
  ক

  Cefuroxime

  খ

  Amoxicillin

  গ

  Azithromycin

  ঘ

  Levofloxacin

  ঙ

  Tetracycline
• The drug combinations that exhibit physiological antagonism are
  ক

  Salbutamol and histamine on bronchioles

  খ

  Prednisolone and insulin on blood glucose level

  গ

  Acetylcholine and adrenaline on heart

  ঘ

  Isoprenaline and propranolol on bronchioles

  ঙ

  Atropine and pilocarpine on pupil
• A competitive antagonist will
  ক

  Cause parallel shifting of dose-response curve to right

  খ

  Not effect to maximal response of the agonist when the dose of agonist is increased

  গ

  Reduce the maximal response of the agonist

  ঘ

  Bind with receptor by co-valent bond

  ঙ

  Enhances affinity of agonist for the receptor
• A competitive antagonist
  ক

  Binds to the same receptor as the agonist

  খ

  Alters the potency of an agonist

  গ

  Shifts the dose response curve of an agonist to the right

  ঘ

  Decreases the maximum response to antagonist

  ঙ

  Alters the efficacy of an agonist
• Drugs correctly paired with their side effects is/are
  ক

  Valproic acid - teratogenesis

  খ

  Carbamazepine - diplopia

  গ

  Phenobarbitone - drug interaction

  ঘ

  Phenytoin - aplastic anemia

  ঙ

  Diazepam - hepatotoxicity
• Beneficial drug combinations is/are
  ক

  Losartan + thiazide

  খ

  Amoxicillin + clavulanic acid

  গ

  Amiloride + thiazide

  ঘ

  Iron + tetracycline

  ঙ

  Aspirin + prednisolone
• Drug interactions can cause therapeutic failure when a patient taking
  ক

  Rifampicin with oral contraceptives

  খ

  Phenobarbitone with warfarin

  গ

  Aspirin with warfarin

  ঘ

  Ciprofloxacin with theophylline

  ঙ

  NSAIDs with methotrexate
• Concurrent use of following drugs leads to the failure of oral contraceptive pill therapy
  ক

  Phenytoin

  খ

  Carbamazepine

  গ

  Paracetamol

  ঘ

  Morphine

  ঙ

  Omeprazole
• Following are partial agonist drugs
  ক

  Clonidine

  খ

  Pindolol

  গ

  Acebutolol

  ঘ

   methyl-dopa

  ঙ

  Reserpine
• Which of the following statements are correct
  ক

  A drug-receptor interaction generally involves co-valent binding

  খ

  The sympathetic supply to the sweat glands is cholinergic

  গ

  Antagonists slowly dissociate from the receptor

  ঘ

  Nicotine is a partial agonist

  ঙ

  β- receptor stimulation causes inhibition of adenylate cyclase
• Which of the following pairs of drugs compete for the same receptor
  ক

  Cimetidine and histamine

  খ

  Strychnine and glycine

  গ

  Dopamine and haloperidol

  ঘ

  Morphine and atropine

  ঙ

  Morphine and noradrenaline
• Drugs act by binding with
  ক

  Enzyme

  খ

  Receptor

  গ

  Ion channel

  ঘ

  Plasma protein

  ঙ

  Hormone
• Drugs producing effects via non-receptor mechanism are
  ক

  Mannitol

  খ

  Magnesium trisillicate

  গ

  Ispaghula

  ঘ

  Sumatriptan

  ঙ

  Morphine
• Drugs acting upon same receptors are
  ক

  Ranitidine and histamine

  খ

  Glycine and strychnine

  গ

  Dopamine and haloperidol

  ঘ

  Atropine and morphine

  ঙ

  Propranolol and ipratropium
• Drugs exert their effect by binding with
  ক

  Carrier proteins

  খ

  Enzymes

  গ

  Receptors

  ঘ

  Plasma proteins

  ঙ

  Smooth endoplasmic reticulum
• Drugs with a high hepatic first-pass effect include
  ক

  Levodopa

  খ

  Morphine

  গ

  Diazepam

  ঘ

  Digoxin

  ঙ

  Phenytoin