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In enzymology, an RNA ligase is an enzyme that catalyzes the chemical reaction

The 3 substrates of this enzyme are ATP, n, and m, whereas its 3 products are AMP, diphosphate, and n+m.

This enzyme belongs to the family of ligases, specifically those forming phosphoric-ester bonds. The systematic name of this enzyme class is poly:poly ligase. Other names in common use include polyribonucleotide synthase , RNA ligase, polyribonucleotide ligase, and ribonucleic ligase.

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