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Butyrate—CoA ligase, also known as xenobiotic/medium-chain fatty acid-ligase , is an enzyme that catalyzes the chemical reaction:
The 3 substrates of this enzyme are ATP, carboxylic acid, and CoA, whereas its 3 products are AMP, diphosphate, and acyl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. This enzyme participates in the glycine conjugation of xenobiotics and butanoate metabolism.
The systematic name of this enzyme class is butanoate:CoA ligase. Other names in common use include:
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