It probably will, depending on how you want it to look. Adding one color will make it a solid color, but mixing can make it rainbow-ish. Mixing it too well might make the colors mix.
It depends on the coloring medium you are using. For some, like colored pencil and shading pencils, you can rub on the pigment and make them blend together. For mediums...
Avoid wearing a t-shirt or something too casual for a top. A button-down top or a polo shirt might be good. Also, try to stick to more classic styles: nothing...