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Regulation of metabolic pathway is done by following ways except one, mark the one?

Regulation of metabolic pathway is done by following ways except one, mark the one? Correct Answer Availability of oxygen

Metabolic pathways depend on the substrate concentration as well as extracellular signals. Coenzymes or certain metabolic intermediate also regulate the metabolism while not all the metabolic pathways depend on the oxygen. Oxygen is required only for aerobic reactions.

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