Metabolism MCQ 119+

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• Type A lactic acidosis is/are found in
  ক

  Carbon monoxide poisoning

  খ

  Severe anemia

  গ

  Ethanol poisoning

  ঘ

  Mitochondrial dysfunction

  ঙ

  Acute liver failure
• Stress causes
  ক

  Lysosomal stabilization

  খ

  Protein mobilization

  গ

  Gluconeogenesis

  ঘ

  Glucose mobilization

  ঙ

  Decrease ACTH secretion
• The aerobic exercise
  ক

  Require energy supply from break down of A TP

  খ

  Causes increase in muscle bulk

  গ

  Helps in development of endurance

  ঘ

  Causes increase in cardiac reserve during exercise by many fold

  ঙ

  Helps in development of muscle strength
• Liver is the only organ that is capable of
  ক

  Urea formation

  খ

  Bile acid synthesis

  গ

  Ganglioside synthesis

  ঘ

  Medium chain fatty synthesis

  ঙ

  Glycogenesis
• Reducing sugars in urine include
  ক

  Glucose

  খ

  Fructose

  গ

  Galactose

  ঘ

  Lactose

  ঙ

  Sucrose
• The basal metabolic rate
  ক

  Increases slightly when walking slowly compared to sitting

  খ

  Is increased following a protein rich meal

  গ

  Is depressed after a meal

  ঘ

  Increased during starvation

  ঙ

  Is reduced in acidosis
• Hepatocellular damage is assessed by estimation of serum
  ক

  Aspartate aminotransferase (AS

  খ

  Alanine aminotransferase (AL

  গ

  Alkaline phosphatase (AL

  ঘ

  5'-nucleotidase (5'-N

  ঙ

  Total protein (T
• Liver function tests are
  ক

  Gamma-glutamyl transpeptidase

  খ

  Serum alanine transaminase

  গ

  Serum aspartate transaminase

  ঘ

  Bleeding time

  ঙ

  Serum globulin
• Polymerase chain reaction PCR requires
  ক

  DNA template

  খ

  Primers

  গ

  Enzymes

  ঘ

  Vectors

  ঙ

  RNA
• Following consequences is/are associated with prolonged starvation
  ক

  Rise of plasma free fatty acid level

  খ

  Rise of plasma ketone body level

  গ

  Lactic acidosis

  ঘ

  Fall in plasma cortisol level

  ঙ

  Rise in urinary nitrogen excretion
• Mitochondrial cytochrome P450 monoxygenase systems play important role in
  ক

  Steroid hormone synthesis

  খ

  1

  গ

  25 dihydroxycholecalciferol formation

  ঘ

  Bile acid synthesis

  ঙ

  Detoxification of drugs and carcinogens

  চ

  Conjugation with glucoronic acid
• Rate determining enzyme of
  ক

  HMP shunt is G6PD

  খ

  Urea cycle is carbamoyl phosphate synthase

  গ

  Glycogenolysis is glycogen phosphorylase

  ঘ

  Cholesterol synthesis is HMG-CoA synthase

  ঙ

  Ketogenesis is HMG-CoA reductase
• Enzymes indicating necrosis in muscle tissues include
  ক

  Lactate dehydrogenase

  খ

  Creatinine phosphokinase

  গ

  Alanine aminotransferase

  ঘ

  Alkaline phosphatase

  ঙ

  Acid phosphatase
• Non-functional plasma enzymes are
  ক

  Lactate dehydrogenase

  খ

  Alkaline phosphatase

  গ

  Creatine kinase

  ঘ

  Prostate specific antigen

  ঙ

  Troponin
• Fates of acetyl CoA are
  ক

  Cholesterol

  খ

  Fatty acid

  গ

  Acetoacetate

  ঘ

  Pyruvate

  ঙ

  Oxaloacetate
• Substances synthesized from acetyl CoA include
  ক

  Ketone body

  খ

  Cholesterol

  গ

  Fatty acid

  ঘ

  Pentose sugar

  ঙ

  Phosphatidylcholine
• Sources of acetyl CoA are
  ক

  β-oxidation of fatty acids

  খ

  Glycolysis

  গ

  Breakdown of ketone bodies

  ঘ

  Krebs cycle

  ঙ

  Breakdown of cholesterol
• Compounds produced from acetyl Co-A are
  ক

  Ketone bodies

  খ

  Cholesterol

  গ

  Fatty acid

  ঘ

  Pentose sugar

  ঙ

  Citric acid
• Pyruvate is metaboliozed by the following enzymes
  ক

  Lactate dehydrogenase

  খ

  Pyruvate carboxylase

  গ

  Alanine aminotransferase

  ঘ

  Phosphoenol pyruvate carboxykinase

  ঙ

  Aspartate aminotransferase
• Metabolic fates of pyruvate are
  ক

  Conversion to acetyl CoA

  খ

  Carboxylation to oxaloacetate

  গ

  Reduction to laclate

  ঘ

  Conversion to fatty acid

  ঙ

  Oxidation to citrate
• Fates of pyruvate in the body are
  ক

  Alanine

  খ

  Oxaloacetate

  গ

  Acetyl CoA

  ঘ

  Glycerol

  ঙ

  Ketoacid formation
• Substrate for pyruvate production are
  ক

  Glucose

  খ

  Alanine

  গ

  Lactate

  ঘ

  Acetyl CoA

  ঙ

  Cholesterol
• Pyruvates are produced from
  ক

  Lactate

  খ

  Alanine

  গ

  Glucose

  ঘ

  Palmitate

  ঙ

  Acetyl CoA
• Pyruvate can be produced from
  ক

  Alanine

  খ

  Lactate

  গ

  Acetyl CoA

  ঘ

  Citrate

  ঙ

  Oxaloacetate
• Fates of pyruvate are
  ক

  Glucose

  খ

  Acetyl-CoA

  গ

  Lactate

  ঘ

  Fatty Acid

  ঙ

  Amino acid leucine
• Fates of pyruvate is/are
  ক

  Alanine

  খ

  Oxaloacetate

  গ

  Glucose

  ঘ

  Tryptophan

  ঙ

  Lysine
• NADPH is
  ক

  Required for fatty acid synthesis

  খ

  Derived mainly from HMP shunt

  গ

  Required for bile acid synthesis

  ঘ

  Used for synthesis of ketone bodies

  ঙ

  Taken up by respiratory chain for ATP production
• NADPH is required for
  ক

  Drug metabolism

  খ

  Generation of superoxide in phagocytes

  গ

  Fatty acid synthesis

  ঘ

  ATP production

  ঙ

  Oxidation of glutathion
• NADPH is required for synthesis of
  ক

  Cholesterol

  খ

  Nitric oxide

  গ

  Fatty acid

  ঘ

  ATP

  ঙ

  Hydrogen peroxide (H2O2)
• NADPH is required for biosynthesis of
  ক

  Cholesterol

  খ

  Fatty acids

  গ

  Ketone bodies

  ঘ

  Porphyrins

  ঙ

  Fat soluble vitamins