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Which among the following disease is caused by inactivating mutations in the tumor suppressor gene encoding menin?

Which among the following disease is caused by inactivating mutations in the tumor suppressor gene encoding menin? Correct Answer Multiple Endocrine Neoplasia Type 1

MEN1 is caused by inactivating mutations that encode menin in the tumor suppressor gene. Menin is a transcription factor widely expressed, that is part of a complex which targets methylation of histone H3 and thus contributes to the development of cell cycle inhibitors in pancreatic islets and other tissues.

Related Questions

Mutations in genes encoding which cyclin-dependent kinase inhibitor is found in MEN1 patients without menin mutations?
Which of the following statements are correct?
P. Viruses can play a role in causing human cancer.
Q. A tumor suppressor gene can be turned off without any change in its DNA sequence.
R. Alteration in miRNA expression levels contributes to the development of cancer.
The first tumor-suppressor gene to be studied is associated with ______________________
ICMR published "National Guidelines for Gene Therapy Product Development and Clinical Trails". Which of the following statements are correct about Gene Therapy Product (GTP)? 1. It is defined as any biological entity, having the required gene, that could introduce modifications in the genome for therapeutic benefit. 2. GTPs work by repairing, replacing or deactivating dysfunctional disease-causing genes to restore normal function. 3. As per the New Drugs and Clinical Trial Rules (2019), the GTPs falls under 'new drug' and shall always be deemed as 'new drug'. 4. Thalassemia, Gaucher's disease, Sickle cell anaemia and Haemophilia fall under the genetically inherited disease category. Select the correct answer using the code given below:
Which of the following statements about gene therapy are correct?
P. Affected individuals, but not their progeny, can be cured through germline gene therapy.
Q. Affected individuals, as well as their progeny, can be cured through germline gene therapy.
R. Affected individuals, but not their progeny, can be cured through somatic gene therapy.
S. Affected individuals, as well as their progeny, can be cured through somatic gene therapy.
Which of the following about Rb tumor suppressor protein is correct?
The followings is/are tumor suppressor genes
Tumor suppressor genes
Which of the following constitutes patentable subject matter?
1. A toxin-where such toxin is found on the skin of a previously unknown tree frog of the Amazon basin, which, when administered to patients with a certain cell cancer, causes a substantial reduction in the number of cancerous cells.
2. An idea-where such idea is that there is a mathematical relation among (i) the exposure time of a tumor to a specified alpha-radiation emitting source, (ii) the size of the tumor in cubic centimeters, and (iii) the success rate of the procedure as determined by survival rate at five years
3. Kidney cells-where such cells are found in a certain variety of wild pigs
4. A new laparoscopic surgical technique-where such technique bears improved results in patient cure
Select the correct answer:
In the following question, sentences of a paragraph have been jumbled and labelled as A, B, C, and D. You are required to rearrange the jumbled sentences of the paragraph and mark your response accordingly by selecting the correct option. A. As genome sequencing has become quicker and cheaper, those studies have become bigger and more complex. B. As a result, they comb through genomes in search of variations in DNA sequences and use statistical tools to determine whether those variations contribute to traits and diseases. C. Researchers clearly cannot intentionally introduce mutations into humans; instead, they must use what nature provides. D. Geneticists have long been able to introduce genetic mutations into model organisms such as the fruit fly — first with X-rays or chemicals, and now with more sophisticated gene-editing tools — where humans are concerned, the toolbox is more limited.