Molecular Endocrinology MCQ

Test your knowledge with important Molecular Endocrinology MCQ and their applications. These MCQs are beneficial for competitive exams too. Explore 30 + more Molecular Endocrinology MCQs at Bissoy

• Mutations in genes encoding which cyclin-dependent kinase inhibitor is found in MEN1 patients without menin mutations?
  ক

  p23 (CD9)

  খ

  p27 (CDKN1B)

  গ

  P53 (LOPERIN)

  ঘ

  p53 (CDKN1B)
• Which among the following disease is caused by inactivating mutations in the tumor suppressor gene encoding menin?
  ক

  Hyperparathyroidism–Jaw Tumor Syndrome

  খ

  Multiple Endocrine Neoplasia Type 1

  গ

  Hyperparathyroidism

  ঘ

  Multiple Endocrine Neoplasia Type 2a
• Parathyroid disease is usually a late and infrequent (5% to 20%) occurrence in patients with which among the following diseases
  ক

  Hyperparathyroidism–Jaw Tumor Syndrome

  খ

  Multiple Endocrine Neoplasia Type 1

  গ

  Hyperparathyroidism

  ঘ

  Multiple Endocrine Neoplasia Type 2a
• Along with PTH and FGF23, which other hormone is involved in the regulation of calcium and phosphate homeostasis?
  ক

  Calcitriol

  খ

  Cholecalciferol

  গ

  Aromatases

  ঘ

  TSH
• Expression of which among the following proteins, increases the renal tubular calcium reabsorption by PTH?
  ক

  CREB protein

  খ

  Calbindin-D28K

  গ

  Calcinone-1123K

  ঘ

  Alloxzine-09K
• Calcitriol also improves intestinal phosphate absorption.
  ক

  True

  খ

  False
• Quantitatively, the most important response to calcium deficiency is enhanced intestinal calcium absorption.
  ক

  True

  খ

  False
• Which among the following is an example of vitamin D analogue?
  ক

  22-oxacalcitriol

  খ

  98-oxocolcalciferol

  গ

  22-cholecalciferol

  ঘ

  Vasotriol-9
• Glucocorticoids have been shown to decrease the expression of the VDR gene in which cell lines?
  ক

  Osteosarcoma cell lines

  খ

  Adenocarcinoma

  গ

  Dalton’s Ascites Lymphoma

  ঘ

  Myeloma
• VDR-RXR heterodimers in the transcriptional activation by 1,25-dihydroxyvitamin D3 repress which enzyme?
  ক

  1α-hydroxylase

  খ

  1α-translocase

  গ

  3-beta aromatases

  ঘ

  Lyase isomerase
• The vitamin D-binding protein (VDBP) has more affinity towards which form of vitamin D?
  ক

  25(OH)D

  খ

  Vitamin D3

  গ

  Ergocalciferol

  ঘ

  Previtamin D
• Vitamin D is absorbed into the lymphatics and enters the circulation by binding to which protein?
  ক

  CBP

  খ

  CREB

  গ

  PRGC

  ঘ

  VDBP
• State whether the given statement is true or false. Fortified dairy products are the main dietary sources of vitamin D.
  ক

  True

  খ

  False
• State whether True or False. Vitamin D is not a true vitamin.
  ক

  True

  খ

  False
• Which among the following is the cutaneous precursor molecule of vitamin D hormone?
  ক

  7-dehydrocholesterol

  খ

  Cholecalciferol

  গ

  Calcitonin

  ঘ

  Parathormone
• Which pancreatic gut hormone is originally isolated as a hypothalamic growth hormone release–inhibiting factor?
  ক

  Somatostatin

  খ

  Secretin

  গ

  Ghrelin

  ঘ

  Motilin
• Which pancreatic gut hormone stimulates pancreatic and biliary bicarbonate and water secretion?
  ক

  Secretin

  খ

  Somatostatin

  গ

  Ghrelin

  ঘ

  Myelin
• Which pancreatic gut hormone is a 13-amino-acid peptide originally detected in bovine hypothalamus?
  ক

  Neurotensin

  খ

  Secretin

  গ

  Amylin

  ঘ

  Motilin
• Immunoreactivity of which pancreatic gut hormone has been detected in open-type enteroendocrine epithelial M cells?
  ক

  Motilin

  খ

  Secretin

  গ

  Gastrin

  ঘ

  Amylin
• Control of ghrelin acylation is regulated by which among the following enzymes?
  ক

  GOAT

  খ

  JAK

  গ

  LAC

  ঘ

  POTRIK
• Which among the following pancreatic gut hormone is a motilin-related peptide growth hormone–releasing factor?
  ক

  Amylin

  খ

  Ghrelin

  গ

  Pepsin

  ঘ

  Gastrin
• Which gastrin-neutralizing antisera has been shown to reduce cell proliferation and induce apoptosis in human colon cancer cells?
  ক

  G-17

  খ

  G-21

  গ

  C-18

  ঘ

  GC-9
• Which pancreatic gut hormone induces proliferation of colon cancer cell lines expressing the CCKBR?
  ক

  Amylin

  খ

  Ghrelin

  গ

  Secretin

  ঘ

  Gastrin
• Which pancreatic gut hormone is produced predominantly in G cells located in the gastric antrum and duodenal bulb?
  ক

  Gastrin

  খ

  Ghrelin

  গ

  Amylin

  ঘ

  Pepsin
• The actions of GIP on the pancreatic beta cell are primarily of which among the following peptides?
  ক

  Inulin

  খ

  Incretin

  গ

  Insulin

  ঘ

  Meurin
• Galanin in humans reduces the levels of plasma insulin.
  ক

  True

  খ

  False
• Three galanin receptor subtypes have been identified worldwide.
  ক

  True

  খ

  False
• Which cells in the intestine secrete GIP, which is also called glucose-dependent insulinotropic polypeptide?
  ক

  Pancreatic acinar cells

  খ

  Gastroendocrine K cells

  গ

  Enteroendocrine K cells

  ঘ

  Pancreaticendocrine F cells
• Which pancreatic hormone was initially isolated from porcine intestine as a 29-amino-acid, C-terminally amidated neuropeptide?
  ক

  Ghrelin

  খ

  Galanin

  গ

  Motilin

  ঘ

  Amylin
• Which among the following CCK regulates hepatic glucose production through a CNS-dependent CCKAR mechanism?
  ক

  CCK-8

  খ

  CCK-23

  গ

  CCK-11

  ঘ

  CCK-33