Mutations in genes encoding which cyclin-dependent kinase inhibitor is found in MEN1 patients without menin mutations?
Mutations in genes encoding which cyclin-dependent kinase inhibitor is found in MEN1 patients without menin mutations? Correct Answer p27 (CDKN1B)
Mutations in genes encoding cyclin-dependent kinase inhibitors such as p27 (CDKN1B) are rarely observed in non-menin mutated MEN1 patients. While MEN1 involves parathyroid, anterior pituitary, and pancreatic islet tumors, the parathyroid tumors are far more prevalent than the others; hyperparathyroidism eventually develops in 95 percent of affected patients.
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Feb 20, 2025