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Doctors Medicines MCQs Q&A

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Tumor suppressor genes
Which of the following about Rb tumor suppressor protein is correct?
The first tumor-suppressor gene to be studied is associated with ______________________
Which among the following disease is caused by inactivating mutations in the tumor suppressor gene encoding menin?
Which of the following statements are correct?
P. Viruses can play a role in causing human cancer.
Q. A tumor suppressor gene can be turned off without any change in its DNA sequence.
R. Alteration in miRNA expression levels contributes to the development of cancer.
Consider the following statements and choose the correct answer:
1. In the phenomenon of linkage and crossing over, the genes are arranged in a linear order in a chromosome
2. The linkage groups in an organism are equivalent to the number of chromosome pairs
3. The chances of crossing over are more between two closely placed genes as compared to the genes placed in far proximity
4. The position of genes is very definite in the chromatid
Consider the following statements regarding the theory of linkage and choose the correct answer:
1. Genes are arranged in a linear fashion in the chromosomes
2. Genes that show linkage are situated in the chromosome
3. Linked genes remain in their original combination during the course of inheritance
4. The genes which are widely separated show strong linkage, while those closely located, have more chances to get separated by crossing over
Which of the following constitutes patentable subject matter?
1. A toxin-where such toxin is found on the skin of a previously unknown tree frog of the Amazon basin, which, when administered to patients with a certain cell cancer, causes a substantial reduction in the number of cancerous cells.
2. An idea-where such idea is that there is a mathematical relation among (i) the exposure time of a tumor to a specified alpha-radiation emitting source, (ii) the size of the tumor in cubic centimeters, and (iii) the success rate of the procedure as determined by survival rate at five years
3. Kidney cells-where such cells are found in a certain variety of wild pigs
4. A new laparoscopic surgical technique-where such technique bears improved results in patient cure
Select the correct answer:
Tumour suppressor genes are
The following sentences form a paragraph. These four parts are numbered as P, Q, R and S. They are not given in their proper order. Read the sentences and choose the alternative that arranges them in correct order. P. The hypothesis was proposed as an explanation for the increased prevalence of type-2 diabetes in certain populations by American geneticist James V. Neel. Q. Thrifty genes refers to a scientific hypothesis which states that obesity in some human beings can be explained by the existence of a ‘thrifty gene’ that aided the storage of excess energy as fat. R. The same genes, however, turned into a biological liability that led to obesity in some people. S. According to the hypothesis, certain genes, by helping in the storage of energy as fat, might have enabled human ancestors live through periods of famine, thus enhancing their chances of survival.