Tumour suppressor genes MCQ 7+

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• Regarding p53 gene
  ক

  It arrests cell cycle in G1 phase

  খ

  It is stimulated by ionizing radiation

  গ

  It is a tumour suppressor gene

  ঘ

  It is associated with adult malignant tumours only

  ঙ

  It is located in chromosome 21
• P53 gene, designated as 'guardian of the genome'
  ক

  Is found in more than 50% human tumours

  খ

  Is a tumor suppressor gene

  গ

  Triggers apoptosis is damaged cell

  ঘ

  Is down regulated following DNA damage of the cells

  ঙ

  Produces tumor when one allele is lost
• Tumour suppressor genes are
  ক

  TP53

  খ

  RB gene

  গ

  APC

  ঘ

  K-RAS

  ঙ

  C-MYC
• Tumor suppressor genes
  ক

  Suppress cancer cell proliferation

  খ

  Are usually recessive in nature

  গ

  Are also known as ‘anti oncogene’

  ঘ

  Also function as gate keeper

  ঙ

  Are responsible for 10% colonic cancers
• BRAF mutation is commonly seen in the following cancers:
  ক

  Malignant melanoma

  খ

  Adenocarcinoma of colorectum

  গ

  Follicular carcinoma of thyroid

  ঘ

  Adenocarcinoma of cervix

  ঙ

  Small cell carcinoma of lung
• TP 53 gene
  ক

  Is regarded as guardian of the genome

  খ

  Is a tumour suppressor gene

  গ

  Is a proto oncogene

  ঘ

  Is activated by viral oncoprotein

  ঙ

  Has no role in DNA repair and apoptosis
• The followings is/are tumor suppressor genes
  ক

  RB

  খ

  APC

  গ

  NF1

  ঘ

  MYC

  ঙ

  ALK