Neoplasm MCQ 209+

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• Regarding brain derived neurotropic factor
  ক

  Increases the neurogenesis

  খ

  Level is modulated by mirtazapine

  গ

  Increases the level of neurotransmitter

  ঘ

  Expression is increased in depression

  ঙ

  Prolonged use may cause anaemia
• Causes of superior vena caval obstruction are
  ক

  Bronchial carcinoma

  খ

  Lymphoma

  গ

  Cervical rib

  ঘ

  Aneurysm of azygos vein

  ঙ

  Retrosternal goiter
• The following malignancy are associated with translocation
  ক

  CML with (9

  খ

  22) (q34;q11)

  গ

  Ewing sarcoma with (11;22) (q24;q12)

  ঘ

  Mantle cell lymphoma with (8

  ঙ

  14) (q24;q32)

  চ

  Burkitt lymphoma with (14;18) (q32;q21)

  ছ

  Follicular lymphoma with (11;14) (q13;q32)
• Basal cell carcinoma
  ক

  Do not normally mestastasize by lymphatic spread

  খ

  Generally grow slowly over many years

  গ

  Frequently occurs on limbs

  ঘ

  Found in younger female

  ঙ

  Are very sensitive to radiotherapy
• Risk factors for basal cell carcinoma are
  ক

  Fair complexion with red hair

  খ

  Radiation therapy

  গ

  Positive family history

  ঘ

  Past history of acne

  ঙ

  Wrinkling
• Wilms tumour
  ক

  Involves both the kidneys in about 5% of cases

  খ

  Usually present as an abdominal mass

  গ

  Has a 2 year survival rate of 90%

  ঘ

  Rarely metastasizes to the lung

  ঙ

  Usually affects adult
• Haemangioma
  ক

  Are hamartomas

  খ

  Can regress spontaneously

  গ

  May be associated with consumpation coagulopathy

  ঘ

  May be associated with organomegaly

  ঙ

  Surgical excision is the only treatment
• Ameloblastoma
  ক

  Is a locally malignant tumour

  খ

  Occurs in young adults

  গ

  Contains enamel

  ঘ

  Is a slow growing tumour

  ঙ

  Maxilla is the commonest site
• Avascular necrosis of bone is caused by
  ক

  Steroid intake

  খ

  Trauma

  গ

  Radiotherapy

  ঘ

  Hemoglobinopathies

  ঙ

  Tuberculosis
• Spontaneous regression of cancer commonly occurs in
  ক

  Breast cancer

  খ

  Renal cell carcinoma

  গ

  Malignant melanoma

  ঘ

  Choriocarcinoma

  ঙ

  Cancer of uterine cervix
• What are the differential diagnosis for unilateral hilar lymphadenopathy
  ক

  Lymphoma

  খ

  Pulmonary tuberculosis

  গ

  Carcinoma

  ঘ

  Emphysema

  ঙ

  Bronchiectasis
• Spontaneous regression of carcinoma commonly occurs in
  ক

  Breast carcinoma

  খ

  Renal cell carcinoma

  গ

  Malignant melanoma

  ঘ

  Cervical carcinoma

  ঙ

  Choriocarcinoma
• Oncogenes
  ক

  Have the ability to promote cell growth in the absence of mitogenic signals

  খ

  Promote autonomous cell growth in cancer cells

  গ

  Product are called oncoproteins

  ঘ

  Are physiologic regulators of cell proliferation and differentiation

  ঙ

  Are biochemical indicators of the presence of a tumour
• Oncogenic DNA viruses are
  ক

  Human papillomavirus

  খ

  Epstein-Barr virus

  গ

  Human T-cell leukaemia virus type I

  ঘ

  Hepatitis C virus

  ঙ

  Cytomegalovirus
• Potentially curable malignancy of childhood are
  ক

  Hodgkin's lymphoma

  খ

  Acute lymphoblastic leukamia

  গ

  Nephroblastoma

  ঘ

  Nasopharyngeal carcinoma

  ঙ

  Renal cell carcinoma
• Common childhood solid tumours are
  ক

  Nephroblastoma

  খ

  Hepatoblastoma

  গ

  Hemangioma

  ঘ

  Lymphangioma

  ঙ

  Hamartoma
• The embryonic tumours of infancy include
  ক

  Nephroblastoma

  খ

  Medulloblastoma

  গ

  Osteogenic sarcoma

  ঘ

  Cholangiocarcinoma

  ঙ

  Lympho-epithelioma
• Childhood malignancy includes
  ক

  Retinoblastoma

  খ

  Nephroblastoma

  গ

  Hepatocellular carcinoma

  ঘ

  Renal cell carcinoma

  ঙ

  Seminoma
• The embryonic tumors of infancy are
  ক

  Nephroblastoma

  খ

  Medulloblastoma

  গ

  Retinoblastoma

  ঘ

  Osteosarcoma

  ঙ

  Cholangiosarcoma
• The embryonic tumors of infancy include
  ক

  Nephroblastoma

  খ

  Medulloblastoma

  গ

  Osteosarcoma

  ঘ

  Cholangiocarcinoma

  ঙ

  Lymphoepithelioma
• Neuroblastomas
  ক

  Are most common in children

  খ

  May differentiate into benign tumours

  গ

  Originate from sympathetic ganglia

  ঘ

  Originate in the adrenal cortex

  ঙ

  Originate in the floor of the fourth ventricle
• Childhood tumour/s is/are
  ক

  Wilm’s tumour

  খ

  Hepatoblastoma

  গ

  Haemangioma

  ঘ

  Carcinoid tumour

  ঙ

  Squamous cell carcinoma
• The following statements regarding Wilms tumours
  ক

  The peak age for presentation is during the third year of life and there is no sex predilection

  খ

  The incidence of familial Wilm’s tumour is more than nonfamilial Wilm’s tumours

  গ

  Hypertesion is seen in 25-60% of cases and is caused by elevated renin levels

  ঘ

  In 50% cases

  ঙ

  the tumours are bilateral

  চ

  Wilm’s tumours usually cross the midline whereas neuroblastoma are typically confined to one side of abdomen
• Regarding p53 gene
  ক

  It arrests cell cycle in G1 phase

  খ

  It is stimulated by ionizing radiation

  গ

  It is a tumour suppressor gene

  ঘ

  It is associated with adult malignant tumours only

  ঙ

  It is located in chromosome 21
• P53 gene, designated as 'guardian of the genome'
  ক

  Is found in more than 50% human tumours

  খ

  Is a tumor suppressor gene

  গ

  Triggers apoptosis is damaged cell

  ঘ

  Is down regulated following DNA damage of the cells

  ঙ

  Produces tumor when one allele is lost
• Tumour suppressor genes are
  ক

  TP53

  খ

  RB gene

  গ

  APC

  ঘ

  K-RAS

  ঙ

  C-MYC
• Tumor suppressor genes
  ক

  Suppress cancer cell proliferation

  খ

  Are usually recessive in nature

  গ

  Are also known as ‘anti oncogene’

  ঘ

  Also function as gate keeper

  ঙ

  Are responsible for 10% colonic cancers
• BRAF mutation is commonly seen in the following cancers:
  ক

  Malignant melanoma

  খ

  Adenocarcinoma of colorectum

  গ

  Follicular carcinoma of thyroid

  ঘ

  Adenocarcinoma of cervix

  ঙ

  Small cell carcinoma of lung
• TP 53 gene
  ক

  Is regarded as guardian of the genome

  খ

  Is a tumour suppressor gene

  গ

  Is a proto oncogene

  ঘ

  Is activated by viral oncoprotein

  ঙ

  Has no role in DNA repair and apoptosis
• The followings is/are tumor suppressor genes
  ক

  RB

  খ

  APC

  গ

  NF1

  ঘ

  MYC

  ঙ

  ALK