What is the length of peptide fragments that are loaded to the MHC class II molecules?
What is the length of peptide fragments that are loaded to the MHC class II molecules? Correct Answer 13-18 amino acids long
MHC class II proteins usually have a length of peptide fragments of 13-25. Endocytic vesicles are acidified which result in activation of proteases. This results in degradation of proteins into fragments. The endocytic vesicles have low pH which means they are acidic and they have more than 40 hydrolases which cuts the antigen into peptides 13-18 amino acids and this length encumbered on MHC II molecules.
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Feb 20, 2025