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Which of the following molecules bind to antigen peptide-MHC class I complex?

Which of the following molecules bind to antigen peptide-MHC class I complex? Correct Answer Tapasin and Calreticulin

Tapasin and Calreticulin are the molecules bind to antigen peptide-MHC class I complexes. Tapasin forms a bridge between TAP proteins with the class I MHC molecules and increases steady state levels of TAP proteins in order to allow more peptides to be translocated in the endoplasmic reticulum (ER). On the other hand, Calreticulin prevents lodging of any other foreign peptides. These molecules are localised to Endoplasmic Reticulum (ER) where it functions as chaperone and regulates the cellular processes.

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