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In an experiment you make two setups, in 1st you knock down the DAM and in 2nd you over express DAM. What will be the observation for both the setups?

In an experiment you make two setups, in 1st you knock down the DAM and in 2nd you over express DAM. What will be the observation for both the setups? Correct Answer In both cases MMR is compromised

DAM knockdown leads to no methylation, and then both strands are indistinguishable as both are not methylated. While in DAM over expression both are methylated at a shorter window giving lesser time for MMR to work. Thus, the MMR in either case is compromised.

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