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If give a segment – 5’CTGACCAUGGCCTAGAUGCCTCT, which AUG will the eukaryotic ribosome choose as initiation site?

If give a segment – 5’CTGACCAUGGCCTAGAUGCCTCT, which AUG will the eukaryotic ribosome choose as initiation site? Correct Answer First

The ribosome scans the mRNA from 5’ end to the 3’ end searching for a Kozak consensus sequence to start at. Here, the 1st AUG indeed has a purin at -3 and +4 position so it is a good initiation site, the ribosome will not look beyond to the 2nd AUG(weaker) and start initiation.

Related Questions

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S. Dissociation of the ribosomal subunits.
T. Translocation of peptidyl-tRNA from the A site to the P site of the ribosome.
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