Initiation MCQ

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• Which of the following is done by HCR?
  ক

  Phosphorylation of eIF4E-BP

  খ

  Phosphorylation of eIF2-alpha

  গ

  Dephosphorylation of eIF4E-BP

  ঘ

  Dephosphorylation of eIF2-Alpha
• Phosphorylation of eIF4E-BP will affect translation in what way?
  ক

  Increase

  খ

  Decrease

  গ

  No effect

  ঘ

  There is no such factor
• Which one of the following has GEF activity?
  ক

  eIF1A

  খ

  eIF2

  গ

  eIF2B

  ঘ

  eIF5
• Which of the following factors prevent reassociation of the 40S and 60S subunits when not bound to the mRNA?
  ক

  eIF1 and eIF3

  খ

  eIF2 and eIF3

  গ

  eIF3 and eIF6

  ঘ

  eIF3 and eIF4
• Which of the following is not a part of eIF4F complex?
  ক

  eIF4A

  খ

  eIF4B

  গ

  eIF4E

  ঘ

  eIF4G
• Which poly a tail binding protein helps in the initiation of translation?
  ক

  CPSF

  খ

  PAP

  গ

  PABP1

  ঘ

  PABP2
• Polysomes are ______________
  ক

  Replication factors

  খ

  Circular

  গ

  Nuclear entity

  ঘ

  Rare phenomenon
• IRES interact with which of the initiation factors?
  ক

  eIF2B

  খ

  eIF4E

  গ

  eIF5

  ঘ

  eIF4G
• Which of the following will not affect translation from the AUG involved?
  ক

  A short hairpin near the cap

  খ

  A hairpin 52 at downstream of cap

  গ

  A long hairpin between cap and initiation codon

  ঘ

  Providing a purine at -3 and +4 position of a start codon
• Which initiation factor in eukaryotes recognizes the 7-M-G cap?
  ক

  eIF4G

  খ

  eIF4B

  গ

  eIF4E

  ঘ

  eIF4A1
• If give a segment – 5’CTGACCAUGGCCTAGAUGCCTCT, which AUG will the eukaryotic ribosome choose as initiation site?
  ক

  Any at random

  খ

  First

  গ

  Second

  ঘ

  None
• Which of the bases are important in detecting whether the AUG should be the start site for eukaryotic initiation?
  ক

  -2 and +3

  খ

  -4 and +3

  গ

  -3 and +4

  ঘ

  -1 and +4
• If you compare the Kozak sequence with the SD sequence of the prokaryotes which is located at the greater distance from the start site?
  ক

  Equal distance

  খ

  Kozak

  গ

  Shine and Dalgarno sequence

  ঘ

  Both are too far to account
• What is used to regulate translation initiation in eukaryotes?
  ক

  Turnover of mRNA

  খ

  Ubiquitination of ribosome

  গ

  Phosphorylation of IF2

  ঘ

  Methylation of IF1a
• Which proteins perform the function of preventing reassociation of ribosomal subunits, when they finish one translation, in eukaryotes?
  ক

  eIF1 and eIF3

  খ

  eIF3 and eIF6

  গ

  eIF2 and eIF4

  ঘ

  eIF3 and eIF5
• If you see a GTP bound IF2 it is _________
  ক

  Before initiation

  খ

  During initiation

  গ

  After initiation

  ঘ

  Not related to an initiation
• Which initiation factor prevents association of ribosome when not bound to mRNA?
  ক

  IF1

  খ

  IF2

  গ

  IF3

  ঘ

  IF4
• IF1 helps in correct placement of the initiation tRNA. How does it do so?
  ক

  By guiding it to P site

  খ

  By binding to A site

  গ

  By dissociating the ribosomal complex

  ঘ

  By binding to the P site
• _____________ treated ribosomes will be able to carry out elongation and termination of previously initiated translation, but can’t initiate any new translation.
  ক

  Streptomycin

  খ

  Rifampicin

  গ

  Tetracyclin

  ঘ

  Colicin E3
• The 16S rRNA binds the mRNA in its ___________ region.
  ক

  Body

  খ

  Head

  গ

  Neck

  ঘ

  Flap