At which position of pyridine electrophilic substitution reaction is most preferred?
At which position of pyridine electrophilic substitution reaction is most preferred? Correct Answer Third
Electrophilic substitution reaction at position the 3-position is preferred over attack at 2 and 4-position because the intermediate found by electrophilic addition at 3-position is more stable as it will have 3-resonating structure and none of will have positive charge on N.
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Feb 20, 2025