Which of the following electrophilic substitution reaction is not possible in pyridine?
Which of the following electrophilic substitution reaction is not possible in pyridine? Correct Answer Friedel craft reaction
Common alkylations and acylations, such as Friedel–Crafts alkylation or acylation, usually fail for pyridine because they lead only to the addition at the nitrogen atom. Substitutions usually occur at the 3-position, which is the most electron-rich carbon atom in the ring and is, therefore, more susceptible to an electrophilic addition.
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Feb 20, 2025