At which position of pyridine nucleophilic substitution reaction is most preferred?
At which position of pyridine nucleophilic substitution reaction is most preferred? Correct Answer Second and Forth
When the nucleophile is at the 2 and 4 positions, the intermediate anion is stabilized by the electronegative nitrogen atom. This results in a more stable anion as compared to the intermediate anion when the nucleophile is at the 3 positions. Hence, the 2 and 4 positions is preferred for nucleophilic substitution.
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Feb 20, 2025