Annotation is based on finding significant alignment to sequences of known function in database similarity searches.

Annotation is based on finding significant alignment to sequences of known function in database similarity searches. Correct Answer True

Accurate annotation of genome sequences is an important first step in genome analysis. Matches of lesser significance provide only a tentative or hypothetical prediction and should be used as a working hypothesis of function.
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Related Questions

If the two sequences share significant similarity, it is extremely ______ that the extensive similarity between the two sequences has been acquired randomly, meaning that the two sequences must have derived from a common evolutionary origin.
The resulting tree is then used to guide the alignment of the most closely related sequences and groups of sequences. The resulting alignment is a global alignment produced by the Needleman-Wunsch algorithm.
Progressive alignment methods use the dynamic programming method to build an MSA starting with the most related sequences and then progressively adding less related sequences or groups of sequences to the initial alignment.
The translated sequence can then be compared to a database of protein sequences with the hope of finding a strong similarity to a protein of known function, and hence to identify the function of the cloned EST.
You are the administrator of a SQL Server 2000 computer. The server contains a database named FinanceData that is used by a client/server application. Each employee has a SQL Server login that the application uses to access the server.Your company hires a new employee named Andrew. You create a SQL Server login named Andrew. You also create a database user named Andrew in the database and grant the database user full permissions in the database.Whenever Andrew runs the client/server application, he receives the following error message: "Invalid object name." Andrew also reports that he cannot access the database by using the application.You need to ensure that Andrew can use the application. Which Transact-SQL statement should you execute?
Related sequences are identified through the database similarity searching and as the process generates multiple matching sequence pairs, it is often necessary to convert the numerous pair wise alignments into a single alignment.
In protein/domain analysis, each protein in the predicted proteome is again used as a query of a curated protein sequence database such as ____ in order to locate similar domains and sequences. To find orthologs, very low E value scores (E<10<20) for the alignment score and an alignment that includes 60–80% of the query sequence are generally required in order to avoid matches to paralogs.
The main application of pairwise alignment is retrieving biological sequences in databases based on similarity.
In EM algorithm, as an example, suppose that there are 10 DNA sequences having very little similarity with each other, each about 100 nucleotides long and thought to contain a binding site near the middle 20 residues, based on biochemical and genetic evidence. the following steps would be used by the EM algorithm to find the most probable location of the binding sites in each of the ______ sequences.
The major drawback of the progressive and iterative alignment strategies is that they are largely global alignment based and may therefore fail to recognize conserved domains and motifs among highly divergent sequences of varying lengths.