The higher the E value, the more significant the alignment between a pair of matching sequences.

The higher the E value, the more significant the alignment between a pair of matching sequences. Correct Answer False

The lower the E value, the more significant the alignment between a pair of matching sequences. The E value of an alignment score is the probability that an alignment score as good as the one found would be observed between two random or unrelated sequences in a search of a database of the same size.
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Who suggested that the global alignment scores between unrelated protein sequences followed the extreme value distribution, similar to local alignment scores? And when?