The whole genome shotgun approach can produce a draft sequence very rapidly because it is based on the direct sequencing approach.

The whole genome shotgun approach can produce a draft sequence very rapidly because it is based on the direct sequencing approach. Correct Answer True

However, it is computationally very demanding to assemble the short random fragments. Although the approach has been successfully employed in sequencing small microbial genomes, for a complex eukaryotic genome that contains high levels of repetitive sequences, such as the human genome, the full shotgun approach becomes less accurate and tends to leave more “holes” in the final assembled sequence than the hierarchical approach. Current genome sequencing of large organisms often uses a combination of both approaches.