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Iterative methods include repeatedly realigning subgroups of the sequences and then by aligning these subgroups into a local alignment of all of the sequences.

Iterative methods include repeatedly realigning subgroups of the sequences and then by aligning these subgroups into a local alignment of all of the sequences. Correct Answer False

Subgroups are aligned into a global alignment of all of the sequences. The objective is to improve the overall alignment score, such as a sum of pairs score. Selection of these groups may be based on the ordering of the sequences on a phylogenetic tree predicted in a manner similar to that of progressive alignment, separation of one or two of the sequences from the rest, or a random selection of the groups.

Related Questions

Progressive alignment methods use the dynamic programming method to build an MSA starting with the most related sequences and then progressively adding less related sequences or groups of sequences to the initial alignment.
The resulting tree is then used to guide the alignment of the most closely related sequences and groups of sequences. The resulting alignment is a global alignment produced by the Needleman-Wunsch algorithm.
The major drawback of the progressive and iterative alignment strategies is that they are largely global alignment based and may therefore fail to recognize conserved domains and motifs among highly divergent sequences of varying lengths.
In the question below, are given a statement followed by three courses of actions numbered I, II and III. On the basis of the information given, you have to assume everything in the statement to be true, and then decide which of the suggested course of action logically follow (s) for pursuing. Statement: Talent management is a term that includes activities such as recruiting, sustaining, developing/progressing and rewarding the talent acquired using the most trusted practices. Gradually, modern-day entrepreneurs understand the ever-increasing importance of talent management practices as this can set the stage for earning high dividend in the long run. In fact, the startups or the well-established firms that fail to acknowledge the potential of aligning its key business strategies with that of its talent management schemes, often find themselves in great trouble down the road. It not just leads to huge wastage of precious resources of the organisation but also make it a fit case for failure in multiple ways.  Courses of action: I. Identifying the organisation’s true purpose and aligning the talent management strategy with it.  II. Letting the channels of communication be open and working effectively for all the employees alike.  III. Analysing huge volume of data with due care and efficiency so as to drive in losses through the masterminds who reside in-house.
Match the items in List - I (Techniques of sampling) with that of List - II (characteristics of procedure). Choose appropriate code for your answer : Set - I (Techniques of sampling) Set – II           (Characteristics of procedure) (a) Purposive sampling (i) Dividing the population into subgroups and taking one or more groups at random (b) Multistage sampling (ii) Researcher relies on his or her own judgment when choosing members from the population (c) Systematic sampling   (iii) Obtaining K ‘interval’ through N/n and using it for constituting the sample (d) Stratified sampling   (iv) Researcher divides the entire population into homogeneous subgroups and randomly selects the final sample
In case of the varying alignment, penalizing gaps heavily might occur. Then the best scoring local alignment between the sequences will be one that optimizes the score between matches and mismatches, without any gaps.
Engines are rated at specified conditions. Then which of the following statements are correct? 1. Power developed increases as local temperature increases. 2. Power developed increases as local temperature decreases 3. Power developed is not dependent on local temperature. 4. Power developed increases as local atmospheric pressure increases. 5. Power developed increases as local atmospheric pressure decreases.
Who suggested that the global alignment scores between unrelated protein sequences followed the extreme value distribution, similar to local alignment scores? And when?
Alignment algorithms, both global and local, are fundamentally similar and only differ in the optimization strategy used in aligning similar residues.
In a multidimensional search matrix, for aligning N sequences, an (N+2)-dimensional matrix is needed to be filled with alignment scores.