Alignment algorithms, both global and local, are fundamentally similar and only differ in the optimization strategy used in aligning similar residues.

Alignment algorithms, both global and local, are fundamentally similar and only differ in the optimization strategy used in aligning similar residues. Correct Answer True

Both types of algorithms can be based on one of the three methods: the dot matrix method, the dynamic programming method, and the word method. The word method is used in fast database similarity searching.

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Who suggested that the global alignment scores between unrelated protein sequences followed the extreme value distribution, similar to local alignment scores? And when?