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In local alignment, the two sequences to be aligned cannot be of unequal lengths.

In local alignment, the two sequences to be aligned cannot be of unequal lengths. Correct Answer False

The two sequences to be aligned can be of different lengths. This approach is more appropriate for aligning divergent biological sequences containing only modules that are similar, which are referred to as domains or motifs. This approach can be used for aligning more divergent sequences with the goal of searching for conserved patterns in DNA or protein sequences.

Related Questions

The resulting tree is then used to guide the alignment of the most closely related sequences and groups of sequences. The resulting alignment is a global alignment produced by the Needleman-Wunsch algorithm.
Progressive alignment methods use the dynamic programming method to build an MSA starting with the most related sequences and then progressively adding less related sequences or groups of sequences to the initial alignment.
The major drawback of the progressive and iterative alignment strategies is that they are largely global alignment based and may therefore fail to recognize conserved domains and motifs among highly divergent sequences of varying lengths.
In the method of extraction of blocks from a global or local MSA, a global MSA of related protein sequences usually includes regions that have been aligned without gaps in any of the sequences.
In case of the varying alignment, penalizing gaps heavily might occur. Then the best scoring local alignment between the sequences will be one that optimizes the score between matches and mismatches, without any gaps.
Who suggested that the global alignment scores between unrelated protein sequences followed the extreme value distribution, similar to local alignment scores? And when?
Iterative methods include repeatedly realigning subgroups of the sequences and then by aligning these subgroups into a local alignment of all of the sequences.
In the program DIALIGN, pairs of sequences are aligned to locate aligned regions that do not include gaps, much like continuous diagonals in a dot matrix plot.
Engines are rated at specified conditions. Then which of the following statements are correct? 1. Power developed increases as local temperature increases. 2. Power developed increases as local temperature decreases 3. Power developed is not dependent on local temperature. 4. Power developed increases as local atmospheric pressure increases. 5. Power developed increases as local atmospheric pressure decreases.
If the two sequences share significant similarity, it is extremely ______ that the extensive similarity between the two sequences has been acquired randomly, meaning that the two sequences must have derived from a common evolutionary origin.