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Where in the cell does the cleavage of B domain (of FVIII) occurs by protease furin?

Where in the cell does the cleavage of B domain (of FVIII) occurs by protease furin? Correct Answer trans region of golgi apparatus

The cleavage of B domain (of FVIII) occurs by protease furin in the trans region of golgi apparatus. It does not occur in the endoplasmic reticulum, mitochondria, or cis region of golgi apparatus. Proteolytic cleavage of FVIII at R-1313 and/or R-1648 by the trans-golgi protease furin results in heterodimer formation.

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