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The FVIII heavy chain and light chain dissociate after cleavage by the furin.

The FVIII heavy chain and light chain dissociate after cleavage by the furin. Correct Answer False

The above statement is false. The FVIII heavy chain and light chain do not dissociate after cleavage by the furin The FVIII heavy chain (A1-a1-A2-a2-B) and light chain (a3-A3-C1-C2) remain associated through non-covalent metal-ion-dependent interactions occurring between the A1 and A3 domains.

Related Questions

Where in the cell does the cleavage of B domain (of FVIII) occurs by protease furin?
Furin Cleavage is necessary for FVIII biological functions.
Read the following passage carefully and choose the most appropriate answer to the question out of the four alternatives.
The human eye is a complex part of the body that is used for seeing. Eyes enable people to perform daily tasks and to learn about the world that surrounds them. Sight, or vision, is a rapidly occurring process that involves continuous interaction between the eye, the nervous system, and the brain. When someone looks at an object, what he really sees is the light reflected from the object. This reflected light passes through the lens and falls on the retina of the eye. Here the light induces nerve impulses that travel through the optic nerve to the brain and then over other nerves to muscles and glands.
The eye is similar to a television camera. Both the eye and the television camera convert light energy to electrical energy. The eye converts light to nerve impulses that are interpreted by the brain as the sense perception called sight. A television camera converts light to electronic signals that are broadcast and transformed into light images in a television receiver. It is wonderful that human eyes blink an average of once every six seconds. This washes the eye with the salty secretion from the tear or lachrymal glands. Each tear gland is about the size and shape of an almond. These glands are situated behind the upper eyelid at the outer corner of the eye. After passing over the eye, the liquid from the gland is drained into the nose through the tear duct at the inner corner of the eye. The sense perception that the brain releases after the eye converts light to nerve impulses is known as
Read the following passage carefully and choose the most appropriate answer to the question out of the four alternatives.
The human eye is a complex part of the body that is used for seeing. Eyes enable people to perform daily tasks and to learn about the world that surrounds them. Sight, or vision, is a rapidly occurring process that involves continuous interaction between the eye, the nervous system, and the brain. When someone looks at an object, what he really sees is the light reflected from the object. This reflected light passes through the lens and falls on the retina of the eye. Here the light induces nerve impulses that travel through the optic nerve to the brain and then over other nerves to muscles and glands.
The eye is similar to a television camera. Both the eye and the television camera convert light energy to electrical energy. The eye converts light to nerve impulses that are interpreted by the brain as the sense perception called sight. A television camera converts light to electronic signals that are broadcast and transformed into light images in a television receiver. It is wonderful that human eyes blink an average of once every six seconds. This washes the eye with the salty secretion from the tear or lachrymal glands. Each tear gland is about the size and shape of an almond. These glands are situated behind the upper eyelid at the outer corner of the eye. After passing over the eye, the liquid from the gland is drained into the nose through the tear duct at the inner corner of the eye. What do we see when we look at an object?
Read the following passage carefully and choose the most appropriate answer to the question out of the four alternatives.
The human eye is a complex part of the body that is used for seeing. Eyes enable people to perform daily tasks and to learn about the world that surrounds them. Sight, or vision, is a rapidly occurring process that involves continuous interaction between the eye, the nervous system, and the brain. When someone looks at an object, what he really sees is the light reflected from the object. This reflected light passes through the lens and falls on the retina of the eye. Here the light induces nerve impulses that travel through the optic nerve to the brain and then over other nerves to muscles and glands.
The eye is similar to a television camera. Both the eye and the television camera convert light energy to electrical energy. The eye converts light to nerve impulses that are interpreted by the brain as the sense perception called sight. A television camera converts light to electronic signals that are broadcast and transformed into light images in a television receiver. It is wonderful that human eyes blink an average of once every six seconds. This washes the eye with the salty secretion from the tear or lachrymal glands. Each tear gland is about the size and shape of an almond. These glands are situated behind the upper eyelid at the outer corner of the eye. After passing over the eye, the liquid from the gland is drained into the nose through the tear duct at the inner corner of the eye. The eye is similar to the television camera because both
Read the following passage carefully and choose the most appropriate answer to the question out of the four alternatives.
The human eye is a complex part of the body that is used for seeing. Eyes enable people to perform daily tasks and to learn about the world that surrounds them. Sight, or vision, is a rapidly occurring process that involves continuous interaction between the eye, the nervous system, and the brain. When someone looks at an object, what he really sees is the light reflected from the object. This reflected light passes through the lens and falls on the retina of the eye. Here the light induces nerve impulses that travel through the optic nerve to the brain and then over other nerves to muscles and glands.
The eye is similar to a television camera. Both the eye and the television camera convert light energy to electrical energy. The eye converts light to nerve impulses that are interpreted by the brain as the sense perception called sight. A television camera converts light to electronic signals that are broadcast and transformed into light images in a television receiver. It is wonderful that human eyes blink an average of once every six seconds. This washes the eye with the salty secretion from the tear or lachrymal glands. Each tear gland is about the size and shape of an almond. These glands are situated behind the upper eyelid at the outer corner of the eye. After passing over the eye, the liquid from the gland is drained into the nose through the tear duct at the inner corner of the eye. The average rate of blinking of an eye is
Read the following passage carefully and choose the most appropriate answer to the question out of the four alternatives.
The human eye is a complex part of the body that is used for seeing. Eyes enable people to perform daily tasks and to learn about the world that surrounds them. Sight, or vision, is a rapidly occurring process that involves continuous interaction between the eye, the nervous system, and the brain. When someone looks at an object, what he really sees is the light reflected from the object. This reflected light passes through the lens and falls on the retina of the eye. Here the light induces nerve impulses that travel through the optic nerve to the brain and then over other nerves to muscles and glands.
The eye is similar to a television camera. Both the eye and the television camera convert light energy to electrical energy. The eye converts light to nerve impulses that are interpreted by the brain as the sense perception called sight. A television camera converts light to electronic signals that are broadcast and transformed into light images in a television receiver. It is wonderful that human eyes blink an average of once every six seconds. This washes the eye with the salty secretion from the tear or lachrymal glands. Each tear gland is about the size and shape of an almond. These glands are situated behind the upper eyelid at the outer corner of the eye. After passing over the eye, the liquid from the gland is drained into the nose through the tear duct at the inner corner of the eye. Lachrymal glands or tear glands are situated
Among six objects F, G, H, J, K and L :  i. H is twice heavy as K, and J is one and half times as heavy as F.  ii. G is half as heavy as J.  iii. F and J together are less heavy than H.  iv. J and L together are twice as heavy as F.  If the objects are arranged in descending order of their weight, which object will be second from the bottom? 
The interaction between FVIII and the Endoplasmic Reticulum (ER) chaperone BiP enhances FVIII secretion.
Which of the following domain is the cleavage site for furin enzyme?