The interaction between FVIII and the Endoplasmic Reticulum (ER) chaperone BiP enhances FVIII secretion.
The interaction between FVIII and the Endoplasmic Reticulum (ER) chaperone BiP enhances FVIII secretion. Correct Answer False
The above statement is false. The interaction between FVIII and the Endoplasmic Reticulum (ER) chaperone BiP limits the FVIII secretions. Disruption of this interaction through specific FVIII amino acid substitutions enhances FVIII secretion 2-fold from mammalian cell culture.