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Arrange the following sequence of collagen synthesis in the correct order. 1) The entrance of polypeptide into the rough endoplasmic reticulum 2) Packaged in to transport vesicle 3) Hydroxylation of lysyl and prolyl residues 4) Formation of tropocollagen 5) Covalent cross-linking of tropocollagen 6) Collection of fibrils

Arrange the following sequence of collagen synthesis in the correct order. 1) The entrance of polypeptide into the rough endoplasmic reticulum 2) Packaged in to transport vesicle 3) Hydroxylation of lysyl and prolyl residues 4) Formation of tropocollagen 5) Covalent cross-linking of tropocollagen 6) Collection of fibrils Correct Answer 1, 3, 4, 2, 5, 6

Biosynthesis of collagen starts with the entry of polypeptides which further involves the formation tropocollagen by hydroxylation of prolyl and lysyl residues. Once tropocollagen is formed, it is packed in to transport vesicle and undergo exocytosis. Fibrils are formed by the lateral covalent cross-linking of tropocollagens.

Related Questions

Consider the following statements regarding Endoplasmic Reticulum: 1. Endoplasmic Reticulum is to act as channels for the transport of materials between different regions of the cytoplasm. 2. The Smooth endoplasmic reticulum helps in the manufacture of fat molecules, or lipids. 3. Ribosomes attached to the surface of the rough endoplasmic reticulum. Which of the statements given above is/are correct?
Given below are four jumbled sentences. Pick the option that gives their correct order. A. According to hair loss experts, excess DHT drastically increases collagen production in the hair follicle. B. Hair loss can be traced to an increase of internal Dihydrotestosterone (DHT) and collagen production. C. Eventually, collagen blocks the pore completely causing a lack of necessary blood flow due to which your hair loses its sheen, thins down and finally you lose your hair completely. D. When too much collagen lines the interior of the follicle, it narrows the pores, decreases blood flow and slowly strangles your hair to death.
The membranes of rough endoplasmic reticulum (RER) and smooth endoplasmic reticulum (SER) are continuous.
___________ collagen represents 90% to 95% of the collagen in ECM and forms fibrils and fibers intertwined with proteoglycan aggregates.
Rough endoplasmic reticulum (RER) looks rough under the microscope because of the attachment of which one of the following cell organelles to its surface?
Rough Endoplasmic Reticulum (RER) looks rough under the microscope because of the attachment of which one of following cell organelles to its surface?
Directions : Following question consists of a statement followed by three arguments I, II and III . You have to decide which of the arguments is a STRONG arguments and which is a WEAK Argument. Statement : Should admission to all professional courses be made on the basis of past academic performance rather than through entrance tests? Arguments : I. Yes. It will be beneficial for those candidates who are unable to bear the expenses of entrance tests. II. Yes. Many deserving candidates securing high marks in their qualifying academic examinations do not perform well on such entrance tests. III. No. The standard of examinations and assessment conducted by different Boards and universities are not comparable and hence there is a need to conduct entrance tests to calibrate them on a common yardstick.
Directions : Following question consists of a statement followed by three arguments I, II and III . You have to decide which of the arguments is a STRONG arguments and which is a WEAK Argument.

Statement : Should admission to all professional courses be made on the basis of past academic performance rather than through entrance tests?

Arguments :
I. Yes. It will be beneficial for those candidates who are unable to bear the expenses of entrance tests.
II. Yes. Many deserving candidates securing high marks in their qualifying academic examinations do not perform well on such entrance tests.
III. No. The standard of examinations and assessment conducted by different Boards and universities are not comparable and hence there is a need to conduct entrance tests to calibrate them on a common yardstick.
The signal sequences are typically _______ residues long, rich in _____ charged residues such as arginines as well as hydroxyl residues such as serines and threonines, but devoid of ______ charged residues.
Which of the following enzyme present in the rough endoplasmic reticulum removes the signal sequence from nascent polypeptides?