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Cancers with hereditary predisposition are
A Carcinoma of breast
B Familial adenomatous polyposis
C Retinoblastoma
D Carcinoma of stomach
E Bronchogenic carcinoma
The following conditions are pre-malignant
A Barrett’s esophagus
B Leukoplakia
C Paget's disease of bone
D Hot nodule of thyroid
E Aphthous ulcer of tongue
Locally malignant conditions are
A Marjolin’s ulcer
B Giant cell tumour
C Rodent ulcer
D Melanoma
E Osteosarcoma
Chronic inflammatory conditions leading to malignant disease are
A Chronic osteomyelitis
B Asbestosis
C Ulcerative colitis
D Crohn’s disease
E Sarcoidosis
Familial adenomatous polyposis
A Leads to adenocarcinoma in untreated case
B Is diagnosed by detection of 100 polyps in the colon
C May develop due to new mutation in germline
D Is an autosomal recessive disorder
E Is known as Lynch syndrome
Regarding familial adenomatous polyposis
A Manifest with numerous adenomatous polyps by age 15 years
B Vast majority develops colorectal cancer by 50 years of age
C Upper gastrointestinal tract is rarely involved
D It is an autosomal recessive disorder
E There is no extra-intestinal features
Familial cancers are
A Breast cancer
B Colorectal cancer
C Medullary cancer of the thyroid
D Papillary cancer of the thyroid
E Stomach cancer
Features that characterize familial cancers arc
A Sometimes bilateral ' multiple tumours
B Tumours arise in two or more close relatives of the index case
C Siblings have 2-3 times greater risk titan unrelated individuals
D Late age at onset
E Associated with specific marker phenotypes
Malignant tumours of the following organs commonly metastasized to bone
A Renal cell carcinoma
B Adenocarcinoma of prostate
C Seminoma of testis
D Gall bladder Adenocarcinoma
E Papillary carcinoma of thyroid
Exfoliative cytology may play role in the diagnosis of the following malignant disorders
A Bronchogenic carcinoma
B Malignant urothelial tumors
C Cervical cancer
D Gastric cancer
E Sino nasal cancer

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