Following malignant conditions have familial predisposition

Cancers with hereditary predisposition are

A

Carcinoma of breast

B

Familial adenomatous polyposis

C

Retinoblastoma

D

Carcinoma of stomach

E

Bronchogenic carcinoma

The following conditions are pre-malignant

A

Barrettâs esophagus

B

Leukoplakia

C

Paget's disease of bone

D

Hot nodule of thyroid

E

Aphthous ulcer of tongue

Locally malignant conditions are

A

Marjolinâs ulcer

B

Giant cell tumour

C

Rodent ulcer

D

Melanoma

E

Osteosarcoma

Chronic inflammatory conditions leading to malignant disease are

A

Chronic osteomyelitis

B

Asbestosis

C

Ulcerative colitis

D

Crohnâs disease

E

Sarcoidosis

Familial adenomatous polyposis

A

Leads to adenocarcinoma in untreated case

B

Is diagnosed by detection of 100 polyps in the colon

C

May develop due to new mutation in germline

D

Is an autosomal recessive disorder

E

Is known as Lynch syndrome

Regarding familial adenomatous polyposis

A

Manifest with numerous adenomatous polyps by age 15 years

B

Vast majority develops colorectal cancer by 50 years of age

C

Upper gastrointestinal tract is rarely involved

D

It is an autosomal recessive disorder

E

There is no extra-intestinal features

Familial cancers are

A

Breast cancer

B

Colorectal cancer

C

Medullary cancer of the thyroid

D

Papillary cancer of the thyroid

E

Stomach cancer

Features that characterize familial cancers arc

A

Sometimes bilateral ' multiple tumours

B

Tumours arise in two or more close relatives of the index case

C

Siblings have 2-3 times greater risk titan unrelated individuals

D

Late age at onset

E

Associated with specific marker phenotypes

Malignant tumours of the following organs commonly metastasized to bone

A

Renal cell carcinoma

B

Adenocarcinoma of prostate

C

Seminoma of testis

D

Gall bladder Adenocarcinoma

E

Papillary carcinoma of thyroid

Exfoliative cytology may play role in the diagnosis of the following malignant disorders

A

Bronchogenic carcinoma

B

Malignant urothelial tumors

C

Cervical cancer

D

Gastric cancer

E

Sino nasal cancer

Following malignant conditions have familial predisposition

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