Familial cancers MCQ 7+

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• Features that characterize familial cancers arc
  ক

  Sometimes bilateral ' multiple tumours

  খ

  Tumours arise in two or more close relatives of the index case

  গ

  Siblings have 2-3 times greater risk titan unrelated individuals

  ঘ

  Late age at onset

  ঙ

  Associated with specific marker phenotypes
• Cancer is a genetic disease because
  ক

  Cells in a cancer are monoclonal

  খ

  Somatic mutations occur in most cancers

  গ

  Mutation of tumor suppressor genes cause cancer

  ঘ

  All cancers show germ line mutation

  ঙ

  Polyploidy is a hallmark of cancer cells
• Familial cancers are
  ক

  Breast cancer

  খ

  Colorectal cancer

  গ

  Medullary cancer of the thyroid

  ঘ

  Papillary cancer of the thyroid

  ঙ

  Stomach cancer
• Cancers with hereditary predisposition are
  ক

  Carcinoma of breast

  খ

  Familial adenomatous polyposis

  গ

  Retinoblastoma

  ঘ

  Carcinoma of stomach

  ঙ

  Bronchogenic carcinoma
• Hereditary neoplasm includes
  ক

  Retinoblastoma

  খ

  Familial polyposis coli

  গ

  Multiple endocrine neoplasia

  ঘ

  Bronchial carcinoma

  ঙ

  Ewing’s sarcoma
• Following malignant conditions have familial predisposition
  ক

  Carcinoma of the breast

  খ

  Colorectal carcinoma

  গ

  Medullary carcinoma of the thyroid

  ঘ

  Renal cell carcinoma

  ঙ

  Hepatocellular carcinoma