Familial adenomatous polyposis

A Leads to adenocarcinoma in untreated case
B Is diagnosed by detection of 100 polyps in the colon
C May develop due to new mutation in germline
D Is an autosomal recessive disorder
E Is known as Lynch syndrome

Correct Answer: Leads to adenocarcinoma in untreated case, Is diagnosed by detection of 100 polyps in the colon, May develop due to new mutation in germline

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Related Questions

Regarding familial adenomatous polyposis
A Manifest with numerous adenomatous polyps by age 15 years
B Vast majority develops colorectal cancer by 50 years of age
C Upper gastrointestinal tract is rarely involved
D It is an autosomal recessive disorder
E There is no extra-intestinal features
Following malignant conditions have familial predisposition
A Carcinoma of the breast
B Colorectal carcinoma
C Medullary carcinoma of the thyroid
D Renal cell carcinoma
E Hepatocellular carcinoma
Familial cancers are
A Breast cancer
B Colorectal cancer
C Medullary cancer of the thyroid
D Papillary cancer of the thyroid
E Stomach cancer
Features that characterize familial cancers arc
A Sometimes bilateral ' multiple tumours
B Tumours arise in two or more close relatives of the index case
C Siblings have 2-3 times greater risk titan unrelated individuals
D Late age at onset
E Associated with specific marker phenotypes

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