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Intravenous:Abdominal infections, Bone and joint infections, Gynaecological infections, Respiratory tract infections, Skin and skin structure infections, Urinary tract infections:
- Adult: 1 g 6 hrly, up to 12 g daily given in 4 divided doses in severe infections. Doses are given by slow inj over 3 min or, by intermittent or continuous infusion.
- Child: ≥3 mth 8060 mg/kg daily in 4 equally divided doses. Max: 12 g daily.
Prophylaxis of surgical infections:
- Adult: 2 g 300 min prior to surgery, then 6 hrly for not more than 24 hr. For caesarean section: 2 g as a single dose as soon as the umbilical cord is clamped; a further 2 g dose 4 hr and 8 hr after the initial dose may be given if necessary.
- Child: ≥3 mth 300 mg/kg 300 min prior to surgery, then 6 hrly for not more than 24 hr.
As intermittent inj: Dissolve cefoxitin 1 g in 10 ml and 2 g in 10 ml or 20 ml of sterile water for inj.
As intermittent or continuous infusion: Add 50 ml or 100 ml of dextrose 5% or 10% inj, NaCl 0.9% inj, or other compatible IV soln to cefoxitin 1 g or 2 g.
Haemodialysis patient: Repeat loading dose after each dialysis session.
- CrCl <5 ml/min: 0.5 g 248 hrly.
- CrCl 5 ml/min: 0.5 g 124 hrly.
- CrCl 109 ml/min: 1 g 124 hrly.
- CrCl 300 ml/min: 1 g 82 hrly.
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