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Intravenous:Bleeding episodes in patients with haemophilia:

• Adult: As activated eptacog alfa: Initially, 90 mcg/kg given via IV bolus over 2 min. Additional dose may be given as needed to achieve or maintain haemostasis, initially 2 hrly. May adjust dose or dosing interval according to response. May continue therapy for up to 3 wk or more in cases of serious bleeding episodes.

Bleeding episodes due to surgery or invasive procedures in patients with factor VII deficiency:

• Adult: As activated eptacog alfa: 150 mcg/kg 4 hrly via IV bolus over 2 min until haemostasis is achieved.

Bleeding episodes due to surgery or invasive procedures in Glanzmann's thrombasthenia:

• Adult: As activated eptacog alfa: 90 mcg/kg 2 hrly via IV bolus over 2 min, give at least 3 doses.

Add the recommended diluent (histidine), swirl gently until dissolved.

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