I was recently given a Rolex Oyster Perpetual watch by a friend. They said it needed to be set because it had not been worn. I reset the time and date, and attempted to wind to get it going but it won't. What's wrong?

Simply moving the watch around should get it to tick for a little bit because they're automatic watches. If it ticks upon being shaken, but won't wind when twisting the crown, that tends to be the mainspring. These tend to be replaced by Rolex dealers preemptively upon regular service, so it's not a huge deal getting it replaced. If it won't even work after being shaken, there's a good chance the movement is bad. Replacement of a movement with OEM parts could easily total the value of the watch. The best thing would be to take it to an expert and them look at it. I would also make sure the watch is authentic before paying to repair it, in case your friend passed a replica off to you.