Usually it's a sign of not adequate watering. Are you soaking it in just water to grow roots, or is it in soil? If it's in water, try changing the water. Don't keep it in the water too long after it grows roots either; there might not be enough nutrients. If it's in soil, water when the soil is dry (stick a toothpick in the soil to test - wet soil sticks to the toothpick) and don't water excessively. Lastly, too much sun can contribute to your problem by drying out the soil quickly, plus pothos prefer indirect sun.

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