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In most cases, it is safe to take Cipro and antidepressants. In my own practice, I have never avoided using Cipro in someone who is on antidepressants, especially for short-term use such as to clear out a bladder infection. However, there is a warning that using ciprofloxacin together with some SSRIs such as sertraline (Zoloft) can increase the risk of an irregular heart rhythm, which may increase the risk of adverse health effects. While an adverse interaction between Cipro and antidepressant is possible, it is a relatively rare side effect.
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