Protein Interactions MCQ
Test your knowledge with important Protein Interactions MCQ and their applications. These MCQs are beneficial for competitive exams too. Explore 30+ more Protein Interactions MCQs on Bissoy. Bissoy App
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The most detailed experimental information about protein-protein interactions comes from three-dimensional structures.
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Structural analyses on small sets of proteins have shown that the domains from a pair of families bind to each other with the same geometry in multi-domain proteins and in transient interactions.
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In the phylogenetic profile method for predicting protein interaction, presence or absence of orthologous genes is scored across a variety of genomes.
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In the assessment of methods to predict protein-protein interactions, one third of such pairs were found to physically interact, and an additional third to belong to the same metabolic pathway or functional process.
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The phylogenetic profile method relies on detection of orthologs (or homologs, in a variation of the method) in a set of genomes.
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Due to the requirement for co-regulation as well as colocalization, the method is mostly limited to certain classes of protein-protein interactions.
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Domains that are part of a multidomain protein are ______
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An approach for predicting ______ to look for cases across a set of genomes where _____ are part of the same gene in one genome resulted in gene fusion method.
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Conservation of gene order due to operon structure is _______ so interactions of proteins specific to eukaryotes cannot be detected by method of Conservation of gene order.
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In a quantitative assessment of this method (Conservation of gene order) using the genome of the parasitic organism Mycoplasma genitalium as a benchmark.
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Members of a stable complex are often co-regulated and thus will be detected by the method of Conservation of gene order.
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When comparing pairs of genes or sets of genes in different genomes for this purpose, it is not mandatory for the genes to be orthologs.
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Genes that are consistently part of the same operon across different, distantly related genomes are likely to be part of the same protein complex or functional process across all species.
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Interactions between proteins can be predicted computationally by looking for sets of genes that occur as a _______
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Experimentation is most desirable over computational methods by every means.
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Which of the following is incorrect about Purification of protein complexes followed by mass spectrometry?
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Which of the following is incorrect about Yeast-two-hybrid screens?
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For proteins in stable complexes the average sequence identity is 46%, while for proteins in transient interactions it is 41%.
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Membership in a stable complex also differs from transient interaction in terms of evolutionary constraints upon sequence divergence.
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Correlation of gene expression for pairs of transiently interacting proteins is ______ compared to randomly chosen pairs of proteins.
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Sets of proteins that are part of stable complexes and sets of proteins involved in transient interactions ____ in terms of the similarity in gene expression among the set of proteins.
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Stable complexes consist of proteins that are _____ associated with each other, like many ____ proteins for instance.
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There exist three types of interactions between domains. Which of the following is not one of them?
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The physical contacts between domains are crucial for the functioning of the cellular machinery.
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Which of the following is untrue regarding the STRING?
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Which of the following is untrue regarding the predicting Interactions Based on Phylogenetic Information?
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In Predicting Interactions Based on Gene Neighbors if a certain gene linkage is found to be indeed conserved across divergent genomes, it can be used as a strong indicator of formation of an operon that encodes proteins that are functionally and even physically coupled.
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The justification behind Rosetta stone method is that when two domains are fused in a single protein, they have to be in _______ proximity to perform a common function.
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When the two domains are located in two different proteins, to preserve the same functionality, their close proximity and interaction have to be preserved as well.
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Which of the following is untrue regarding the Predicting Interactions Based on Domain Fusion?