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Give an example of the dorsally expressed transcription factor determined by the FGF8 gradient that is expressed in the diencephalon?

Give an example of the dorsally expressed transcription factor determined by the FGF8 gradient that is expressed in the diencephalon? Correct Answer Nkx-3.1

The BMP2 ventral-dorsal signal and the FGF8 dorsalventral signal tend to produce gradients of opposing activity that are suggested to dictate overlapping patterns of particular transcription factors. Dorsal cell phenotypes are determined by the FGF8 gradient, and dorsally expressed transcription factors include Nkx-3.1, Six3, Pax6, and PIT11 prophet (PROP1).

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