Which hormone increases the conversion of cholesterol to pregnenolone in glucocorticoid synthesis?
Which hormone increases the conversion of cholesterol to pregnenolone in glucocorticoid synthesis? Correct Answer ACTH
ACTH improves the conversion of cholesterol to pregnenolone which is the “rate-limiting” phase. By the activity of G-6-PD and phosphogluconate dehydrogenase, ACTH also stimulates the HMP-shunt pathway.