Which enzyme helps in the conversion of 11-deoxycortisol to cortisol in the final step of glucocorticoid synthesis?
Which enzyme helps in the conversion of 11-deoxycortisol to cortisol in the final step of glucocorticoid synthesis? Correct Answer 11-β-hydroxylase
11-deoxycortisol is transported to mitochondrion and is converted to ‘cortisol’ by the enzyme 11-β-hydroxylase. This is the final step toward glucocorticoid formation. Glucocorticoids (GCs) are immunoregulatory hormones synthesized in the adrenal cortex under physiological and stress conditions and secreted into the blood in a circadian manner.