Glucocorticoids MCQ 3+

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• Which hormone increases the conversion of cholesterol to pregnenolone in glucocorticoid synthesis?
  ক

  Insulin

  খ

  ACTH

  গ

  Cortisol

  ঘ

  ADH
• What is the role of ACTH in the formation of cortisol?
  ক

  Stimulates the synthesis of glucocorticoids

  খ

  Inhibits the synthesis of glucocorticoids

  গ

  Inhibits the synthesis of mineralocorticoids

  ঘ

  Stimulates the synthesis of mineralocorticoids
• Which enzyme helps in the conversion of 11-deoxycortisol to cortisol in the final step of glucocorticoid synthesis?
  ক

  17-beta-hydroxylase

  খ

  17-alpha-hydroxylase

  গ

  18-beta-hydroxylase

  ঘ

  11-β-hydroxylase
• Which enzyme helps in the conversion of 17-OH-progesterone to 11-deoxycortisol in the third step of glucocorticoid synthesis?
  ক

  21-hydroxylase enzyme

  খ

  17-beta-hydroxylase

  গ

  17-alpha-hydroxylase

  ঘ

  18-beta-hydroxylase
• In the second step of glucocorticoid synthesis 17-OH pregnenolone is converted to which molecule?
  ক

  11-deoxycortisol

  খ

  17-OH progesterone

  গ

  Corticosterone

  ঘ

  Retinoid
• It is possible to synthesise Pregnenolone and progesterone from acetate.
  ক

  True

  খ

  False
• The three hydroxylase enzymes in the glucocorticoid formation, are all Cyt-P450-containing mono-oxygenases.
  ক

  True

  খ

  False
• Which hormone helps in the conversion of Pregnenolone to 17-OH pregnenolone in the synthesis of glucocorticoids?
  ক

  17-beta-hydroxylase

  খ

  18-alpha-hydroxylase

  গ

  17-alpha-hydroxylase

  ঘ

  18-beta-hydroxylase
• Which enzyme helps in the conversion of cholesterol to Pregnenolone in the steroid hormone biosynthesis pathway?
  ক

  Cytochrome-P470- sidechain cleavage enzyme

  খ

  Cytochrome-P450-sidechain cleavage enzyme

  গ

  NADH dehydrogenase

  ঘ

  Carboxylase
• Side effects of corticosteroids are
  ক

  Hypertension

  খ

  Psychosis

  গ

  Osteopenia

  ঘ

  Gum hyperplasia

  ঙ

  Impaired glomerular filtration rate
• Hair growth is influenced by
  ক

  Thyroid hormones

  খ

  Growth hormone

  গ

  Testosterone

  ঘ

  Cortisol

  ঙ

  Parathyroid hormone
• Corticosteroids possessing potent mineralocorticoid activity
  ক

  Deoxycorticosterone

  খ

  Aldosterone

  গ

  Cortisol

  ঘ

  Prednisolone

  ঙ

  Dexamethasone